Download Adrenocortical Carcinoma: Basic Science and Clinical by David E. Schteingart (auth.), Gary D. Hammer, Tobias Else PDF

By David E. Schteingart (auth.), Gary D. Hammer, Tobias Else (eds.)

This first variation of the textbook “Adrenocortical Carcinoma: uncomplicated Sciences and medical suggestions” offers a concise compilation of correct information advancing our present figuring out of this infrequent melanoma. Chapters are devoted to a variety of elements of either the fundamental biology and the scientific technology in relation to adrenocortical carcinoma (ACC). specialist clinicians introduce the reader to present cutting-edge medical care of sufferers with ACC. As a substantial physique of information on ACC has gathered over the past a long time, specialist scientists have authored extra sections that function a reference resource for the skilled researcher in addition to an creation for the trainee within the laboratory or hospital. scientific themes span the epidemiology, analysis and treatment of ACC. clinical themes parts span the pathology and pathophysiology of ACC with a distinct specialise in experimental types of adrenocortical tumors and up to date advances within the genetic features and signaling pathways in ACC. The content material of this publication was once compiled and edited with the motive of facilitating the interpretation of data into destiny diagnostic and healing instruments that would eventually increase sufferer care.

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By David E. Schteingart (auth.), Gary D. Hammer, Tobias Else (eds.)

This first variation of the textbook “Adrenocortical Carcinoma: uncomplicated Sciences and medical suggestions” offers a concise compilation of correct information advancing our present figuring out of this infrequent melanoma. Chapters are devoted to a variety of elements of either the fundamental biology and the scientific technology in relation to adrenocortical carcinoma (ACC). specialist clinicians introduce the reader to present cutting-edge medical care of sufferers with ACC. As a substantial physique of information on ACC has gathered over the past a long time, specialist scientists have authored extra sections that function a reference resource for the skilled researcher in addition to an creation for the trainee within the laboratory or hospital. scientific themes span the epidemiology, analysis and treatment of ACC. clinical themes parts span the pathology and pathophysiology of ACC with a distinct specialise in experimental types of adrenocortical tumors and up to date advances within the genetic features and signaling pathways in ACC. The content material of this publication was once compiled and edited with the motive of facilitating the interpretation of data into destiny diagnostic and healing instruments that would eventually increase sufferer care.

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Extra resources for Adrenocortical Carcinoma: Basic Science and Clinical Concepts

Sample text

Both size and appearance of an adrenal mass are usually well suited to differentiate benign and malignant adrenocortical lesions. 7 cm (ranging from 3 to 40 cm), making size alone a highly valuable parameter to assess malignancy. Most ACCs are inhomogeneous with areas of necrosis or hemorrhage, with irregular margins, and occasionally with calcifications [57]. Ultrasound. Sonography is an inexpensive and safe method that detects adrenal lesions larger than 2–3 cm. However, it is strongly user-dependent and sonographic evaluations poorly characterize solid adrenal lesions.

Am J Med 41(4):572–580 29. Allolio B (2001) Adrenal incidentalomas. In: Margioris AN, Chrousos GP (eds) Adrenal disorders. Humana, Totawa, NJ, pp 249–261 30. Hamwi GJ et al (1957) Does adrenocortical hyperplasia result in adrenocortical carcinoma. N Engl J Med 257(24):1153–1157 3 Epidemiology of Adrenocortical Carcinoma 29 31. Abiven G et al (2006) Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients.

Nevertheless, these epidemiological studies have to be assessed with caution, because in none of the cases ACC was confirmed by histological reports and in some patients adrenal metastases of lung cancer may have been misdiagnosed as ACC. Accordingly, a recent review on tobacco use and cancer 3 Epidemiology of Adrenocortical Carcinoma 25 causation judged the available evidence for an association of smoking and ACC as too weak to draw firm conclusions [27]. No clear association was found for alcohol use, height and weight, or food consumption patterns in either sex [24].

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